SEENEL IMAGING

Research-based from INSERM lab, Seenel Imaging commercializes Medelopt®, a breakthrough neuroimaging device.

Developed by world-renowned clinical neuroscience and signal processing researchers, along with a well-rounded team of electronic onboarding
and medical devices experts, Medelopt® is the perfect multimodal functional brain exploration platform for neuroscientific researchers.

2004
2009
2011
2014
2018

2004

Fabrice Wallois, a neuroscientific researcher at INSERM U-1105 / Amiens Picardy University and neurophysiologist at the University Hospital in Amiens, headed a multidisciplinary team of researchers, engineers and clinicians. They initiated research into new signal acquisition and cerebral function analysis tools.

2009

INPI innovation Award

2011

”OSEO Emergence” Award

2014

Medelopt®, an innovative cerebral neuro-imaging system is patented

2018

Seenel Imaging is founded to develop this paradigm-shifting neuro-imaging device.

OUR TECHNOLOGY

Pr. Fabrice Wallois

Pr. Fabrice Wallois
Clinical and Neuroscientific Advisor
Head of the Pediatric Clinical Neurophysiology Department at Amiens Picardy Hospital
Director of the Multimodal Analysis of Brain Function Research Group, Inserm UMR 1105

“My research focuses on the analysis and maturation of neural networks, be they respiratory or cortical, physiological or pathological, in children and in animals. We have developed tools that make it possible to describe electric (EEG) and metabolic (NIRS) activities. Their modulations in pathological situations, as well as tracking the sources of these cerebral activities in children, and particularly prematurely so, are central to this research. In 2004, we created the GRAMFC, an innovation that allows simultaneous analysis of modifications in electric (High resolution EEG) local hemodynamic (High Resolution NIRS, Optical imaging) cerebral activity, both physiologically (cerebral maturation) and for pathological conditions (anoxic ischemia in premature babies, prenatal neurological suffering, and convulsions/epilepsy in children). With its combination of neuropsychologists, intensive care paediatricians, and signal processing experts, our research unit (EA4293) was recognized both in 2008 by the French Ministry of Research and in 2010 by the Inserm (U 1105).”

1. Schematic diagram of the functional NIRS (fNIRS). NIR-lights are generated and guided to the human’s head via optical fibers or cables. Another fiber bundle or cable directs diffusively reflected light from the head to detectors. A light detector captures the light resulting from the interaction with the chromophores (e.g. HbO, HbR), following a crescent-shaped path back to the surface of the skin. fNIRS takes advantage of the living tissue’s absorbing properties in the near-infrared range to measure changes in the local concentrations of oxy- and deoxy-hemoglobin ([HbO] and [HbR]) through intact skulls. Light in the NIR spectral range (650–950 nm ‘optical window’) can penetrate relatively deeply (a few centimeters) into the brain tissue, mostly because NIR light is only slightly absorbed by water, collagen, and proteins. fNIRS is performed by emitting near-infrared light into the scalp and detecting the transmitted light at certain positions.

2. EEG measures the sum total activity of the electrical signals that the brain sends to the scalp. EEG signals – as distinct from the fNIRS, which measures brain activity indirectly (i.e., changes in oxygenation) – are therefore generated directly through neuronal activity. The fNIRS’s spatial resolution is better than the EEG’s, and the EEG’s temporal resolution is better than the fNIRS’s

EEG vs. fMRI vs. fNIRS
Sample EEG Signal
Sample EEG Signal
Schematic diagram of the functional NIRS
Schematic diagram of the functional NIRS

Research-based**
(INSERM U1105/UPJV/CHU Amiens Picardy)
and protected by 3 patents,
Medelopt® is a breakthrough innovative multimodal

functional cerebral neuroimaging device.

Medelopt® provides high quality measurements
of changes in oxy and deoxy-haemoglobin
simultaneously with electric potentials.

 

**Safaie.J et al. (2013)

KEY FEATURES

High density bimodality
fNIRS/EEG

Hemodynamic (with 512 channels) & featuring electrical signal acquisition, Medelopt® provides accurate measurements for in-vivo 2D/3D functional brain mapping.
LED: 16 emitters / Electropods: 32 receptors / 8 EEG electrodes

Sophisticated technology
crafted for Wearability

Medelopt® miniaturisation allows acquisitions on moving patients.

Designed for getting direct access
to the scalp

Due to its unique design structure, Medelopt® solves the hair constraint which is the main fNIRS-related constraint that researchers encounter. LED-emitters LED and electropods come directly in contact with the scalp’s skin.

Customized
headset setup

Thanks to the headset design, sensor placement (emitters/Receptors and EEG electrodes) can be set up to record the whole head, from the cognitive to the visual area.

Long recording
is now possible

Pressure zones are distributed homogeneously and uniformly around the head.  Beacause of this, long recordings are made possible.

APPLICATIONS

Video of the dynamic appearance of NIRS results in a patient with epilepsy with a central initial focus that spreads in the frontal regions during an epileptic interictal spike.

EPILEPSY RESEARCH

Epilepsy involves complex mechanisms that combine neuronal, astrocytic, and vascular interactions, particularly within the neurovascular coupling involved in epileptic spikes and seizures.

The simultaneous analysis of various neuronal and vascular compartments by the EEG in tandem with the NIRS makes it possible to see the mechanisms involved and their interactions by a multimodal, multidimensional approach. Additionally, this simultaneous approach combines the EEG’s high temporal resolution with the high spatial resolution of the NIRS

COGNITIVE NEUROSCIENCE

The point of a wearable device for cognitive neuroscience that evaluates brain function in response to sensory stimulation lies essentially in the possibility of developing ecological stimuli that minimic everyday life situations in the best way possible. With a wearable device, it becomes possible to map out the brain structures involved in tasks such as driving or sports in real-life situations, as opposed to what is possible with fMRIs.

DBS/VSN

The appeal of the device lies in its compatibility with devices that involve electrical stimulation of the central (Deep Brain Stimulation (DBS)) or peripheral (Vagus Nerve Stimulation (VSN)) nervous system. This device thus makes it possible to map out the structures of the cortical surface that are modulated by these stimuli without having them be generated within the constraints of the electric fields produced by the stimulation or the constraints of magnetic fields inherent to MRIs and that make these maps difficult to produce in cases of DBS and VNS.

epilepsy-bg-4

WHO WE ARE

Thomas Fontaine

Thomas Fontaine
CEO and Founder

An expert with 25 years of experience in business development, sales, and marketing in the medical devices field.

Alexandre Harly

Alexandre Harly
CTO

15 years of experience as an electronic & software engineer, with a strong entrepreneurial streak.

Fabrice Wallois

Pr. Fabrice Wallois
Clinical and Neuroscientific Advisor

Head of the Pediatric Clinical Neurophysiology Department at Amiens Picardy Hospital
Director of the Multimodal Brain Function Analysis Research Group, Inserm UMR 1105

Mahdi Mahmoudzadeh

Mahdi Mahmoudzadeh
PhD, Neuroscientific and
Biomedical Advisor

Research scientist, Faculty of Medicine, INSERM U1105 Laboratory, Picardy University
Hospital Engineer, Southern Hospital of Amiens, France

CONTACT